Seminar-Regulation of receptor mobility and spatial organization in B cell activation & Seminar-Incorporating data science into undergraduate microbiology 

THE UNIVERSITY OF BRITISH COLUMBIA
Department of Microbiology and Immunology
presents a seminar by:
Dr. Libin Abraham & Dr. Kim Dill-McFarland
Research Associate - Dr. Gold Lab & Postdoctoral fellow - Dr. Hallam Lab; Dept. of Microbiology and Immunology, UBC
entitled:
Regulation of receptor mobility and spatial organization in B cell activation & Incorporating data science into undergraduate microbiology

   

Dr. Libin Abraham- B cells bind to antigen via B cell receptor (BCR) that initiates BCR signaling, B cell activation and antibody production. However even in the absence of antigen, the BCR continually generates a low-level of antigen-independent ‘tonic’ signaling. The strength of this tonic BCR signaling determines whether a B cell is in a resting, partially activated (primed), or activated state prior to encountering antigen. My research aim is to understand how spatial distribution and dynamics of plasma membrane receptors regulate tonic BCR signaling and B cell activation, using super resolution imaging and single particle tracking. Our results show that increased tonic BCR signaling in primed B cells is associated primarily with changes in the mobility and spatial organization of IgM-BCRs and the co-receptor CD19, as opposed to IgD-BCRs.

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Dr. Kim Dill-McFarland- The world is increasingly inundated with data. This is especially acute in the life sciences where next-generation sequencing has created a tidal wave of multi-omic information. As a result, the major challenge in microbiology has shifted from data generation to processing and interpretation. This necessitates training in data science, an interdisciplinary field linking big data with statistics, mathematics, and computer science. Toward this goal, the Experiential Data science for Undergraduate Cross-disciplinary Education (EDUCE) initiative at the U. of British Columbia is creating a broadly deliverable and flexible program for undergraduate data science education in microbiology.

Sponsored by:

The Department of Microbiology and Immunology

 

Tuesday, April 2, 2019 - 12:30pm to 1:30pm

Location:
Life Sciences Centre, LSC 3
2350 Health Sciences Mall
Hosted by
Dr. Michael Gold