Seminar-Polysialic acid: from microbes to humans
presents a seminar by:
Candidate for Faculty Position
Polysialic acid is a long carbohydrate which is important for cell migration in humans. In healthy adults, it is required for learning, memory and immune function. However, in cancer patients, it strongly correlates with metastasis and poor prognosis. Certain pathogenic bacteria can also employ polySia to evade the immune system and cross the blood-brain barrier. I have used biochemistry, chemical biology, proteomics and mass cytometry to study many aspects of polySia biology. In this talk, I will take you through my journey in determining the structure and biosynthesis of bacterial polySia-based capsules, discovering novel polysialylated proteins in human cancers, and modifying therapeutic proteins with polySia to improve their pharmacokinetics.
The Department of Microbiology and Immunology