Seminar-Polysialic acid: from microbes to humans

THE UNIVERSITY OF BRITISH COLUMBIA
Department of Microbiology and Immunology
presents a seminar by:
Dr. Lisa Willis
Post-doctoral fellow, Department of Chemistry, University of Toronto
entitled:
Polysialic acid: from microbes to humans

Candidate for Faculty Position

Polysialic acid is a long carbohydrate which is important for cell migration in humans. In healthy adults, it is required for learning, memory and immune function. However, in cancer patients, it strongly correlates with metastasis and poor prognosis. Certain pathogenic bacteria can also employ polySia to evade the immune system and cross the blood-brain barrier. I have used biochemistry, chemical biology, proteomics and mass cytometry to study many aspects of polySia biology. In this talk, I will take you through my journey in determining the structure and biosynthesis of bacterial polySia-based capsules, discovering novel polysialylated proteins in human cancers, and modifying therapeutic proteins with polySia to improve their pharmacokinetics. 

Sponsored by:

The Department of Microbiology and Immunology

Tuesday, January 23, 2018 - 12:30pm to 1:30pm

Location:
Life Sciences Centre, LSC 3
2350 Health Sciences Mall
Hosted by
Dr. Rachel Fernandez