Seminar-Evolution of the bacterial outer membrane

THE UNIVERSITY OF BRITISH COLUMBIA
Department of Microbiology and Immunology
presents a seminar by:
Dr. Elitza Tocheva
Assistant Professor, Faculty of Dentistry, University of Montreal
entitled:
Evolution of the bacterial outer membrane

The outer membrane (OM) of bacteria is the first line of defense against the environment and provides protection against toxic compounds such as antibiotics. In addition, it can elicit a strong host immunogenic response. Yet, little is known about the origin and evolution of the OM. Our studies on sporulating Gram-positive and Gram-negative bacteria using electron cryotomography, phylogenetic analyses and biochemical approaches reveal extensive peptidoglycan and membrane remodeling during sporulation. Furthermore, we show that an ancient sporulation-like event may have given rise to the OM in bacteria and that subsequent loss-of-function events led to the diversity of modern bacterial cell plans. Increased knowledge of the biology and biogenesis of the OM will facilitate the development of antimicrobials for antibiotic-resistant Gram-negative bacteria.

Sponsored by:

The Department of Microbiology and Immunology

Tuesday, January 30, 2018 - 12:30pm to 1:30pm

Location:
Life Sciences Centre, LSC 3
2350 Health Sciences Mall
Hosted by
Dr. Rachel Fernandez