Seminar - Imaging the microenvironments that shape the immune response
presents a seminar by:
The immune system is composed of a large array of innate and adaptive cell populations. Each of these is endowed with unique functions, and the collective action of multiple cell types is necessary for optimal immunity and protection. Quantitative imaging approaches are now revealing that these diverse cells are also asymmetrically distributed across lymphoid organs, creating unique immune microenvironments and engaging in selective cell-cell interactions. We are now beginning to reveal how these microenvironments influence the generation of responses, finding that they are critical for acquisition of draining antigens during immunization and infection, as well as in guiding the activation and differentiation of CD4+ and CD8+ T cells.
The Department of Microbiology and Immunology