Seminar-Hit-Optimization of intramacrophage active compounds against Mycobacterium tuberculosis

Department of Microbiology and Immunology
presents a seminar by:
Dr. Abraham López
Postdoctoral Fellow, Av-Gay Lab
Hit-Optimization of intramacrophage active compounds against Mycobacterium tuberculosis

Dr. Abraham López is a UBC post doctoral fellow  at the GSK-DDW Tres Cantos Open Lab Foundation. Abraham led  the hit profiling and optimization of a set of active intracellular compounds against intracellular Mycobacterium tuberculosis.   The talk will provide an educational overview of the accomplishments and setbacks during the hit optimization campaign and  will focus in the full profiling and of a novel prodrug against Mtb. Abraham will describe medicinal chemistry efforts covering the identification of key chemical modifications required for improving potency and mitigating series liabilities as well as the research carried out to elucidate the compound mechanism of action. 

Sponsored by:

The Department of Microbiology and Immunology

Tuesday, May 22, 2018 - 12:30pm to 1:30pm

Life Sciences Centre, LSC 3
2350 Health Sciences Mall
Hosted by
Dr. Yossef Av-Gay