Seminar - Bringing protein motion to the center of drug discovery: from molecular wiggles to breakthrough therapies

THE UNIVERSITY OF BRITISH COLUMBIA
Department of Microbiology and Immunology
presents a seminar by:
Dr. Pascal Fortin
Vice President and Head of Biochemistry, Biophysics & Structural Biology, Relay Therapeutics
entitled:
Bringing protein motion to the center of drug discovery: from molecular wiggles to breakthrough therapies

Despite great advances in the discovery of targeted small molecule therapies, most validated targets in human disease remain undrugged. Failures experienced in pharmaceutical research are often attributed to 1) limitation of current drug discovery tools and 2) a myopic view of target function and modulation. The first part of the seminar will cover recent progress in drugging an oncology target thus far deemed undruggable. The second part of the seminar will focus on the drug discovery platform being developed at Relay Therapeutics where protein motion is brought to the center of drug generation. I will discuss how computation (including long timescale MD simulations) and experimentation (including non-cryo crystallography and conformational assays) are being integrated to shrink the undruggable world and uncover new therapeutic opportunities in areas of high unmet medical need.

Sponsored by:

The Department of Microbiology and Immunology

Tuesday, September 26, 2017 - 12:30pm to 1:30pm

Location:
Life Sciences Centre, LSC 3
2350 Health Sciences Mall
Hosted by
Dr. Lindsay Eltis