Seminar - Bringing protein motion to the center of drug discovery: from molecular wiggles to breakthrough therapies
presents a seminar by:
Despite great advances in the discovery of targeted small molecule therapies, most validated targets in human disease remain undrugged. Failures experienced in pharmaceutical research are often attributed to 1) limitation of current drug discovery tools and 2) a myopic view of target function and modulation. The first part of the seminar will cover recent progress in drugging an oncology target thus far deemed undruggable. The second part of the seminar will focus on the drug discovery platform being developed at Relay Therapeutics where protein motion is brought to the center of drug generation. I will discuss how computation (including long timescale MD simulations) and experimentation (including non-cryo crystallography and conformational assays) are being integrated to shrink the undruggable world and uncover new therapeutic opportunities in areas of high unmet medical need.
The Department of Microbiology and Immunology