Welcome to the Jean Lab in the LSC

PRINCIPAL INVESTIGATOR: François Jean, Ph.D.

 

DR. JEAN’S MAJOR RESEARCH GOAL

Since 1999, my lab has been leading a major research initiative funded by Canadian Institutes of Health Research (CIHR) to discover novel broad-spectrum antiviral agents directed at human enveloped viruses of great concern in Canada and worldwide, including hepatitis C virus, influenza A virus, and dengue virus.

 

DR. JEAN’S CURRENT PROJECTS

-> Hijacking of host cell pathways by human enveloped viruses and discovery of novel indirect-acting antiviral agents (IAAs)

-> Discovery of novel direct-acting antiviral agents (DAAs) targeting virally encoded proteases

-> Exosomal MicroRNAs: Discovery of new master regulators of viral infection and blood-based diagnostic biomarkers of human viral diseases

-> Next generation molecular diagnostics for emerging viral diseases

 

DR. JEAN’S NEW ANTIVIRAL RESEARCH PROGRAMS AT THE STATE-OF-THE-ART RESEARCH FACILITY FINDER (FACILITY FOR INFECTIOUS DISEASE AND EPIDEMIC RESEARCH).

With the recent establishment of FINDER at UBC, one of the most important facilities of its kind in the world, I have expanded my antiviral research program towards the discovery of broad-spectrum antivirals directed at emerging and re-emerging viruses of concern in Canada and around the world (e.g., West Nile virus, highly pathogenic H5/H7 influenza A viruses, and HIV-1). Funded by CFI and BCKDF infrastructure grants and under my directorship, FINDER is equipping Canadian and international research collaborators with state-of-the-art resources that allow them to apply the cutting-edge tools of genomics, proteomics, and imaging (i.e., infectomics) to the study of host-pathogen interactions and discovery of novel antimicrobial agents and biomarkers.

 

READ MORE ON FINDER UNDER DR. JEAN’S DIRECTORSHIP

-> FINDER Web Page

 

READ MORE ON DR. JEAN’S RESEARCH PROGRAMS:  ARTICLE PUBLISHED IN SYNERGY: THE JOURNAL OF UBC SCIENCE

-> “Viral Attack Strategies: Multiple Pathways to Pandemic Preparedness”

 

RESEARCH and DISCOVERY (2012-2013)

Dr. Jean’s Illustration — Interaction of HIV-1 virions with host cell during the HIV life cycle.
Clinical Chemistry (Volume 59, Number 8, August 2013)

 

EMPLOYMENT OPPORTUNITIES

Postdoctoral Fellow: 
If you are interested in working on our projects as a postdoctoral fellow, please send your CV and the names of three references to Dr. François Jean via email.

Graduate Student Program: 
Graduate students can enter the Jean Lab via the Dept. of Microbiology and Immunology Program.

Co-op Student Program: We usually have one or two Co-op students in the lab each year. If you are interested, contact Dr. François Jean via email.

Summer Research Opportunities: We usually have one or two summer students in the lab each year. If you are interested, contact Dr. François Jean via email.