Publications

Complete publication list in Google Scholar

 

Selected Recent Publications

  1. Bowden, C.M.F., Verstraete, M.M., Eltis, L.D. & Murphy, M.E.P. (2014) The IsdB NEAT domain 1 of Hemoglobin binding and catalytic heme extraction by IsdB NEAT domains. Biochemistry. 53, 2286-94.
  2. Kobylarz, M.J., Grigg, J.C., Takayama, S.J., Rai, D.Y., Heinrichs, D.E., and Murphy, M.E.P. (2014) Synthesis of L-2,3-diaminopropionic acid, a siderophore and antibiotic precursor. Chem. & Biol. (Cell Press). 21, 379-88.
  3. Saer, R.G., Pan, J., Hardjasa, A., Lin, S., Rosell, F., Mauk, A.G., Woodbury, N.W., Murphy, M.E.P. & Beatty, J.T. (2014) Structural and kinetic properties of Rhodobacter sphaeroides photosynthetic reaction centers containing exclusively Zn-coordinated bacteriochlorophyll as bacteriochlorin cofactors. Biochem. Biophys. ACTA. 1837, 366-74.
  4. De, S., Chan, A.C.K., Coyne, H.J., Okon, M., Murphy, M.E.P., Graves, B.J. and McIntosh, L.P. (2014) Steric mechanism of auto-inhibition regulation of specific and non-specific DNA binding by the ETS transcriptional repressor ETV6. J. Mol. Biol. 426, 1390-406.
  5. Loutet, S.A., Kobylarz, M.J. Chau, C.H.T. & Murphy, M.E.P. (2013) IruO is a reductase for heme degradation by IsdI and IsdG proteins in Staphylococcus aureus. J. Biol. Chem. 288, 25749-59.
  6. Pfaffen, S., Abdulqadir, R., Le Brun, N.E. & Murphy M.E.P. (2013) Mechanism of ferrous iron binding and oxidation by ferritin from a pennate diatom. J. Biol. Chem. 288, 14917-25.
  7. Saer, R.G., Hardjasa, A., Rosell, F., Mauk, A.G., Murphy, M.E.P. & Beatty, J.T. (2013) The role of Rhodobacter sphaeroides photosynthetic reaction center residue M214 amino acid in the composition, light-absorption properties, and conformations of HA and BA cofactors. Biochemistry 52, 2206-17.
  8. Singh, R., Grigg, J.C., Wei, Q., Kadla, J.F., Murphy, M.E.P. & Eltis, L.D. (2013) Improved manganese-oxidizing activity of DypB, a peroxidase from a lignolytic bacterium. ACS Chem. & Biol. 8, 700-6.
  9. Cadieux, B., Lian, T., Hu, G., Wang, J., Biondo, C., Teti, G., Liu, V., Murphy, M.E.P., Creagh, A.L. & Kronstad, J.W. (2013) The mannoprotein Cig1 supports iron acquisition from heme and virulence in the pathogenic fungus Cryptococcus neoformans. J. Infect. Dis. 207, 1339-47.
  10. Cheung, J., Murphy, M.E.P. & Heinrichs, D.E. (2012) Discovery of a novel, iron-regulated citrate synthase in Staphylococcus aureus. Chem. & Biol. (Cell press), 19, 1568-78.
  11. Ukpabi, G., Takayama, S.J., Mauk, A.G. & Murphy, M.E.P. (2012) Inactivation of IsdI heme oxidation by an active site substitution that diminishes heme ruffling. J. Biol. Chem. 287, 34179-88.
  12. Freeman, J.O., Murphy, M.E.P. & Sherman, J.C. (2012) Monomer-dimer control and crystal engineering in TASPs. Chemistry. 18, 11409-16.
  13. Singh, R., Grigg, J.C., Armstrong, Z., Murphy, M.E.P. & Eltis, L.D. (2012) The distal heme pocket residues of a B-type dye-decolorizing peroxidase: arginine but not aspartate is essential for peroxidase activity. J. Biol. Chem. 287, 10623-30.
  14. Grigg, J.C., Mao, C.X., & Murphy, M.E.P. (2011) Iron coordinating tyrosine is a key determinant of NEAT domain heme transfer. J. Mol. Biol. 413: 684-98.
  15. Takayama, S.J., Ukpabi, G., Murphy*, M.E.P. & Mauk*, A.G. (2011) Electronic properties of the highly ruffled heme center of the heme degrading enzyme IsdI. Proc. Nat. Acad. Sci., 108: 13071-6.
  16. Koch, D., Chan, A.C.K., Murphy, M.E.P., Lilie, H., Grass, G. & Nies, D.H. (2011) Characterization of a novel dipartite iron uptake system from uropathogenic Escherichia coli strain F11. J. Biol. Chem. 286, 25317-30.
  17. Gaudin, C.F.M., Grigg, J.C., Arrieta, A.L., & Murphy, M.E.P. (2011) Unique axial tyrosine and methionine heme iron coordination in a NEAT domain from Staphylococcus aureus IsdB. Biochemistry, 50, 5443-52. (Citations 24)
  18. Roberts, J.N., Singh, R., Grigg, J.C., Murphy, M.E.P., Bugg, T.D.H. and Eltis, L.D. (2011) Characterization of DyP peroxidases from Rhodococcus jostii RHA1. Biochemistry, 50, 5108-19. (Citations 23)
  19. Grigg, J.C., Cheung, J., Heinrichs, D.E., Murphy, M.E.P. (2010) Specificity of staphyloferrin B recognition by the SirA receptor from Staphylococcus aureus. J. Biol. Chem. 285, 34579-88. (Citations 21)
  20. Chan, A.C.K., Doukov, T.I, Scofield, M., Tom-Yew, S.A.L., Ramin, A., MacKichan, J.K., Gaynor, E.C. & Murphy. M.E.P. (2010) Structure and function of P19, a high affinity iron transporter of the human pathogen Campylobacter jejuni. J. Mol. Biol. 401, 590-604.
  21. Grigg, J.C., Cooper, J.D., Cheung, J., Heinrichs, D.E., Murphy, M.E.P. (2010) The Staphylococcus aureus siderophore receptor, HtsA, undergoes localized conformational changes to enclose staphyloferrin A in an Arg-rich binding pocket. J. Biol. Chem. 285, 11162-71. (Citations 30)
  22. Reniere, M.L., Ukpabi, G., Harry, S.R., Stec, D.F., Wright, D.W., Bachmann, B.O., Murphy, M.E.P., Skaar, E.P. (2010) A conserved heme oxygenase from pathogenic bacteria degrades heme to a novel chromophore. Mol. Microbiol. 75, 1529-38. (Citations 46)
  23. MacPherson, I.S, Rosell, F.I., Scofield, M., Mauk, A.G. & Murphy, M.E.P. (2010) Directed evolution of copper nitrite reductase to a chromogenic reductant. Prot. Eng. Design Sel. 24, 137-45.
  24. Wong, S.G., Tom-Yew, S.A.L., Lewin, A.C., Le Brun, N., Moore, G.R., Murphy, M.E.P. & Mauk, A.G. (2009) Structural and mechanistic studies of a stabilized subunit dimer variant of Escherichia coli bacterioferritin identify residues required for core formation. J. Biol. Chem. 284, 18873-81.
  25. Freeman, J.O., Lee, W.C., Murphy, M.E.P. & Sherman, J.C. (2009) X-ray crystal analysis of a TASP: structural insights of a cavitein dimer. J. Amer. Chem. Soc. 131, 7421-9.
  26. Zhao, L., Nguyen, N.T., Fernandez, R.C. & Murphy, M.E.P. (2009) Crystallographic characterization of the passenger domain of the Bordetella autotransporter BrkA. Acta Crystallogr. F. 65, 608-11.
  27. Beasley, F.C., Vines, E.D., Grigg, J.C., Zheng, Q., Murphy, M.E.P. & Heinrichs, D.E. (2009) Identification of a second genetic locus involved in siderophore biosynthesis in Staphylococcus aureus: characterization of siderophore biosynthetic and iron-siderophore transport mutants. Mol. Microbiol. 72, 947-63. (Citations 47)
  28. Marchetti, A., Parker, M.S., Moccia, L.P., Lin, E.O., Arrieta, A.L., Murphy, M.E.P., Maldonado, M.T. & Armbrust, E.V. (2009) Ferritin is used for iron storage in bloom-forming marine pennate diatoms. Nature 457, 467-470. (Citations 115)