Osborne Lab - Publications

  1. Tait-Wojno ED, Monticelli LA, Tran SV, Alenghat T, Osborne LC, Thome J, Willis C, Budelsky A, Farber DL, Artis D. (2015) The prostaglandin D2 receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung. Mucosal Immunology; advance online publication 8 April 2015, doi:10.1038/mi.2015.21.
     
  2. Zaiss DMW, Gause WC, Osborne LC, Artis D. (2015) Emerging functions of amphiregulin in orchestrating immunity, inflammation and tissue repair. Immunity 42: 216-226. (Review)
     
  3. Bain CC, Bravo-Blas A, Scott CL, Perdiguero EG, Geissmann F, Henri S, Malissen B, Osborne LC, Artis D, Mowat AM. (2014) Constant replenishment from circulating monocytes maintains the macrophage pool in adult intestine. Nature Immunology 15: 929-937.
     
  4. Conti HR, Peterson AC, Brane L, Huppler AR, Hernandez-Santos N, Whibley N, Hamilton K, Whibley N, Hamilton K, Garg AV, Simpson-Abelson MR, Gibson GA, Mamo AJ, Osborne LC, Rosborogh BR, Bishu S, Ghilardi N, Siebenlist U, Watkins SC, Artis D, Thomson A, Kane LP, McGeachy MJ, Gaffen SL. (2014) Oral-resident ‘natural’ Th17 cells and gd T cell control opportunistic Candida albicans infections. The Journal of Experimental Medicine 211: 2075-2084
     
  5. Osborne LC, Monticelli LA, Nice TJ, Sutherland TE, Siracusa MC, Hepworth MR, Tomov VT, Kobuley D, Tran SV, Bittinger K, Laughlin A, Bailey AG, Boucher J-L, Wherry EJ, Bushman FR, Allen JE, Virgin HW, Artis D. (2014) Virus-helminth co-infection reveals a microbiota-independent mechanism of immuno-modulation. Science 345: 578-582.
     
  6. Wolf AI, Strauman MC, Mozdzanowska K, Williams KL, Osborne LC, Shen H, Liu Q, Garlick D, Artis D, Hensley SE, Caton AJ, Weiser JN, Erikson J. Pneumolysin expression by Streptococcus pneumoniae protects colonized mice from Influenza virus-induced disease. Virology 462-463: 254-265.
     
  7. Chen B, Chan AJ, Chung JI, Jang JC, Osborne LC, Nair MG. (2014) Polarizing the T helper 17 response in Citrobacter rodentium infection via expression of resistin-like molecule a. Gut Microbes 5: 363-368.
     
  8. Patton DT, Plumb AW, Redpath SA, Osborne LC, Perona-Wright G, Abraham N. (2014) The development and survival but not function of follicular B cells is dependent on IL-7Ra Tyr449 signaling. PLoS One. 9: e88771.
     
  9. Siracusa MC, Saenz SA, Tait Wojno ED, Osborne LC, Kim BS, Ziegler C, Benitez AJ, Ruymann KR, Farber DL, Sleiman PM, Hakonarson H, Cianferoni A, Wang ML, Spergel JM, Comeau MR and Artis D. (2013) TSLP-mediated extramedullary hematopoiesis promotes allergic inflammation. Immunity 39: 1158-1170.
     
  10. Alenghat T, Osborne LC, Saenz SA, Kobuley D, Ziegler CGK, Mullican SE, Choi I, Grunberg S, Sinha R, Wynosky-Dolfi M, Snyder A, Hoang T, Bewtra M, Brodsky IE, Sonnenberg GF, Bushman FD, Won K-J, Lazar MA, Artis D. (2013) Histone deacetylase 3 orchestrates commensal bacteria-dependent intestinal homeostasis. Nature 504: 153-157.
     
  11. Tomov VT*, Osborne LC*, Dolfi DV, Sonnenberg GF, Monticelli L, Mansfield K, Virgin HW, Artis D, Wherry EJ. (2013) Persistent enteric Murine Norovirus infection is associated with functionally suboptimal CD8 T cell responses. Journal of Virology 87: 7015-7031.
    *These authors contributed equally to this work.
     
  12. Osborne LC, Joyce KL, Alenghat T, Sonnenberg GF, Giacomin PR, Du Y, Bergstrom KS, Vallance BA, Nair MG. (2013) Resistin-like molecule (RELM) a promotes Th17 cell responses and bacterial-induced colitis. Journal of Immunology 190: 2292-2300.
     
  13. Abt MC, Osborne LC, Monticelli LA, Doering T, Alenghat T, Sonnenberg GF, Paley MA, Antenus, M, Williams KL, Erikson J, Wherry EJ, Artis D. (2012) Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity 37: 158-170.
     
  14. Osborne LC, Patton DT, Seo JH, Abraham N. (2011) Elevated IL-7 availability does not account for T cell proliferation in moderate lymphopenia. The Journal of Immunology 186; 1981-1988.
     
  15. Osborne LC, Duthie KA, Gascoyne RD, Abraham N. (2010) Selective ablation of the YxxM motif suppresses lymphomagenesis but maintains lymphocyte development. Oncogene 29: 3854-3864.
     
  16. Osborne LC, Abraham N. (2010) Regulation of memory T cells by gc cytokines. Cytokine 50: 105-113. (Review)
     
  17. Osborne LC, Dhanji S, Snow JW, Priatel JJ, Ma MC, Miners JM, Teh H-S, Goldsmith MA, Abraham N. (2007) CD8 T cell memory and CD4 T cell primary immune response defects in IL-7Ra mutant mice. The Journal of Experimental Medicine 204: 619-631.
     
  18. Duthie KA, Osborne LC, Foster LJ, Abraham N. (2007) Proteomic analysis of IL-7 induced signaling effectors show selective changes in IL-7Ra449F knock-in T cell progenitors. Molecular & Cellular Proteomics 6: 1700-1710.
     
  19. Burke RD, Osborne L, Wang D, Murabe N, Yaguchi S, Nakajima Y. (2006) Neuron-specific expression of a synaptotagmin gene in the sea urchin, Strongylocentrus purpuratusJournal of Comparitive Neurology 496: 244-51.