Cancelled-Seminar-Drug-sniffing bacteria – using bacterial behaviour to uncover new antibiotics
presents a seminar by:
As resistance continues to increase, we urgently need to identify and develop new antibiotics or antibiotic adjuvants that can enhance and preserve the activity of our current arsenal. We found that a wide variety of antibiotic classes stimulate bacterial biofilm at subinhibitory concentrations, a form of stress response to sublethal damage. We exploit this behaviour in small molecule screens to alert us to the presence of antimicrobials whose concentrations are too low to inhibit growth – the standard readout for activity. I will present two vignettes illustrating how we used biofilm stimulation to discover new activities in a library of previously FDA-approved, off patent drugs, and discuss how we are working to make behaviour-based assays even more amenable to high throughput screening.
The Department of Microbiology and Immunology