Seminar-Dancing from Bottoms Up - Roles of the transcription factor Kaiso in colon and breast cancer
presents a seminar by:
UBC Microbiology alumnus (Dr. Weeks Lab)
The POZ-ZF transcription factor Kaiso was discovered almost two decades ago as a binding partner for the cell adhesion co-factor p120ctn. Since its discovery, roles for Kaiso in diverse biological processes, including the epithelial-to-mesenchymal transition (EMT), apoptosis and inflammation have emerged. Kaiso has been linked to canonical Wnt, TGFb, EGFR, and Notch signalling pathways and thus Kaiso has been implicated in multiple human cancers including colorectal, breast, prostate and lung cancers. In some human cancers, high Kaiso expression correlates with tumor metastasis and poor prognosis. Increasing evidence also points to a role for Kaiso in the racial disparities in cancer incidence and mortality in people of African Ancestry.
The Department of Microbiology and Immunology