Seminar-Dancing from Bottoms Up - Roles of the transcription factor Kaiso in colon and breast cancer

THE UNIVERSITY OF BRITISH COLUMBIA
Department of Microbiology and Immunology
presents a seminar by:
Dr. Juliet M. Daniel
Professor, Dept. of Biology and Acting Associate Dean of Research & External Relations, Faculty of Science, McMaster University
entitled:
Dancing from Bottoms Up - Roles of the transcription factor Kaiso in colon and breast cancer

UBC Microbiology alumnus (Dr. Weeks Lab)

The POZ-ZF transcription factor Kaiso was discovered almost two decades ago as a binding partner for the cell adhesion co-factor p120ctn. Since its discovery, roles for Kaiso in diverse biological processes, including the epithelial-to-mesenchymal transition (EMT), apoptosis and inflammation have emerged. Kaiso has been linked to canonical Wnt, TGFb, EGFR, and Notch signalling pathways and thus Kaiso has been implicated in multiple human cancers including colorectal, breast, prostate and lung cancers. In some human cancers, high Kaiso expression correlates with tumor metastasis and poor prognosis. Increasing evidence also points to a role for Kaiso in the racial disparities in cancer incidence and mortality in people of African Ancestry.

https://ubc.zoom.us/meeting/register/u5ckfuipqD8vGNLUlt7wRCB6ZleIvlABq4uT

Sponsored by:

The Department of Microbiology and Immunology

Monday, November 23, 2020 - 1:00pm to 2:00pm

Location:
Virtual Seminar - on Zoom
Hosted by
Dr. Michael Gold