Seminar-Microbial pharmacologists - Insights into the impact of host-microbe interactions on drug efficacy and toxicity
presents a seminar by:
Traditionally, pharmacologists have approached the concepts of efficacy and toxicity with a very reductionist perspective, solely focusing on target tissues and key organs that drive detoxification and metabolism processes. However, it is now apparent that the intestinal microbiota can have direct and indirect effects on drug detoxification/metabolism through the action of their own enzymes and through regulating the expression/function of host enzymes, respectively.
The Department of Microbiology and Immunology