Gaynor Lab - Publications

Ha, R., Frirdich, E., Sychantha, D., Biboy, J., Taveirne, M.E., Johnson, J.G., DiRita, V.J., Vollmer, W., Clarke, A.J., and Gaynor, E.C. (2016). "Accumulation of peptidoglycan O-acetylation leads to altered cell wall biochemistry and negatively impacts pathogenesis factors of Campylobacter jejuni." J. Biol Chem. (in press)

Liu, Y., Frirdich, E., Taylor, J.A., Chan, A.C., Blair, K.M., Vermeulen, J., Ha, R., Murphy, M.E., Salama, N.R., Gaynor, E.C., and Tanner, M.E. (2016). "A bacterial cell shape-determining inhibitor." ACS Chem Biol. 11(4):981-91

Cameron, A., Huynh, S., Scott, N.E., Frirdich, E., Apel, D., Foster, L.J., Parker, C.T., and Gaynor, E.C. (2015). "High-frequency variation of purine biosynthesis genes is a mechanism of success in Campylobacter jejuni.MBio. 6(5):e00612-15 

Svensson, S.L., Huynh, S., Parker, C.T., Gaynor, E.C. (2015). "The Campylobacter jejuni CprRS two-component regulatory system regulates aspects of the cell envelope." Mol Microbiol. 96(1):189-209

Chan, A.C., Blair, K.M., Liu, Y., Frirdich, E., Gaynor, E.C., Tanner, M.E., Salama, N.R., and Murphy, M.E. (2014). "Helical shape of Helicobacter pylori requires an atypical glutamine as a zinc ligand in the carboxypeptidase Csd4." J Biol. Chem. 290(6):3622-38

Svensson, S.L., Pryjma, M., and Gaynor, E.C. (2014). "Flagella-mediated adhesion and extracellular DNA release contribute to biofilm formation and stress tolerance of Campylobacter jejuni." PLoS One 9(8):e106063. doi: 10.1371

Stahl, M., Ries, J., Vermeulen, J., Yang, H., Sham, H.P., Crowley, S.M., Badayeva, Y., Turvey, S.E., Gaynor, E.C., Li, X., and Vallance, B.A. (2014). "A novel mouse model of Campylobacter jejuni gastroenteritis reveals key pro-inflammatory and tissue protective roles for Toll-like receptor signaling during infection." PLoS Pathog. 10(7): e1004264. doi: 10.1371

Cameron, A., and Gaynor, E.C. (2014). "Hygromycin B and Apramycin antibiotic resistance cassettes for use in Campylobacter jejuni". PLoS One 9(4):e95084. doi: 10.1371

Frirdich, E., Vermeulen, J., Biboy, J., Soares, F., Taveirne, M.E., Johnson, J.G., DiRita, V.J., Girardin, S.E., Vollmer, W., and Gaynor, E.C. (2014). "Peptidoglycan LD-carboxypeptidase Pgp2 influences Campylobacter jejuni helical cell shape and pathogenic properties, and provides the substrate for the DL-carboxypeptidase Pgp1". J Biol. Chem. 289(12):8007-18

Frirdich, E., and Gaynor, E.C. (2013). "Peptidoglycan hydrolases, bacterial shape, and pathogenesis". Current Opinion in Microbiology 16:1-12

Cameron, A., Frirdich, E., Huynh, S., Parker, C.T., and Gaynor, E.C. (2012). "Hyperosmotic stress response of Campylobacter jejuni". J Bacteriol. 194(22):6116-30

Pryjma, M., Apel, D., Huynh, S., Parker, C.T., and Gaynor, E.C. (2012). "FdhTU-modulated formate dehydrogenase expression and electron donor availability enhance recovery of Campylobacter jejuni following host cell infection". J Bacteriol. 194(15):3803-13

Frirdich, E., Biboy, J., Adams, C., Lee, J., Ellermeier, J., Davis Gielda, L., DiRita, V.J., Girardin, S.E., Vollmer, W., and Gaynor, E.C. (2012). "Peptidoglycan-modifying enzyme Pgp1 is required for helical cell shape and pathogenicity traits in Campylobacter jejuni". PLoS Path. 8(3): e1002602, doi: 10.1371/journal.ppat.1002602

Szymanski, C.M. and Gaynor, E.C. (2012). “How a sugary bug gets through the day: recent developments in understanding fundamental processes impacting Campylobacter jejuni pathogenesis” Gut Microbes Special Issue on Enteric Pathogens, Mar 1;3(2):135-44

Gaynor, E.C. and Szymanski, C.M. (2012). “The 30th Anniversary of Campylobacter, Helicobacter and Related Organisms Workshops – What Have We Learned in Three Decades?” Frontiers in Cellular and Infection Microbiology, doi: 10.3389/fcimb.2012.00020.

Apel, D., Ellermeier, J., Pryjma, M., DiRita, V.J., and Gaynor, E.C. (2012).  "Characterization of Campylobacter jejuni RacRS reveals roles in the heat shock response, motility, and maintenance of cell length homogeneity". J Bacteriol. 194(9):2342-54

Martinez-Gutierrez, F., Thi, E.P., Silverman, J.M., de Oliveira, C.C., Svensson, S.L., Vanden Hoek, A., Sanchez, E.M., Reiner, N.E., Gaynor, E.C., Pryzdial, E.L., Conway, E.M., Orrantia, E., Ruiz., F., Av-Gay, Y., and Bach, H. (2011). "Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles". Nanomedicine 8(3):328-36.

Li, X., Apel, D., Gaynor, E.C., and Tanner, M.E. (2011). "5-methylthioadenosine nucleosidase is implicated in playing a key role in a modified futalosine pathway for menaquinone biosynthesis in Campylobacter jejuni. J Biol Chem. 286(22):19392-8

Chan, A.C., Doukov, T.I., Scofield, M., Tom-Yew, S.A., Ramin, A.B., Mackichan, J.K., Gaynor, E.C., and Murphy, M.E. (2010). "Structure and function of P19, a high-affinity iron transporter of the human pathogen Campylobacter jejuni. J Mol Biol. 401(4):590-604.

Dalebroux, Z.D., Svensson, S.L., Gaynor, E.C., and Swanson, M.S. (2010). "ppGpp conjures bacterial virulence". Microbiol Mol Biol Rev. 74(2):171-99. Review.

Naito, M., Frirdich, E., Fields, J.A., Pryjma, M., Li, J., Cameron, A., Gilbert, M., Thompson, S.A., and Gaynor, E.C. (2010). "Effects of sequential Campylobacter jejuni 81-176 lipooligosaccharide core truncations on biofilm formation, stress survival, and pathogenesis". J Bacteriol. 192(8):2182-92.

Lin, A.E., Krastel, K., Hobb, R.I., Thompson, S.A., Cvitkovitch, D.G., and Gaynor, E.C. (2009). "Atypical roles for Campylobacter jejuni amino acid binding cassette transporter components PaqP and PaqQ in bacterial stress tolerance and pathogen-host cell dynamics". Infect Immun. 77(11):4912-24.

Svensson, S.L., Davis, L.M., MacKichan, J.K., Allan, B.J., Pajaniappan, M., Thompson, S.A., and Gaynor, E.C. (2009) “The CprS sensor kinase of the zoonotic pathogen Campylobacter jejuni influences biofilm formation and is required for optimal chick colonization". Mol Microbiol. Jan; 71(1):253-72.

Thompson, S.A., and Gaynor, E.C. (2008). "Campylobacter jejuni host tissue tropism: a consequence of its low-carb lifestyle?" Cell Host Microbe Nov; 13:4(5)409-10.

Champion, O.L., Valdez, Y., Thorson, L., Guttman, J.A., Menendez, A., Gaynor, E.C., and Finlay, B.B. (2008) “A murine intra peritoneal infection model reveals that host resistance to Campylobacter jejuni is Nramp1 dependent”. Microbes Infect. July; 10(8):922-927.

Svensson, S.L., Frirdich, E., and Gaynor, E.C. (2008) “Survival strategies of Campylobacter jejuni: stress responses, the viable but non-culturable state, and biofilms.” Invited book chapter for Campylobacter, Third Edition, C.M. Szymanski, I. Nachamkin, and M.J. Blaser, eds. (Herndon, VA: ASM Press), pp. 62–85.

Pajaniappan, M., Cawthraw, S.A., Newell, D.G., Gaynor, E.C., Fields, J.A., Rathbun, K., Hall, J.E., Burns, C.M., Kelly, D.J., and  Thompson, S.A.. (2008) “A temperature-regulated Campylobacter jejuni gluconate dehydrogenase is involved in respiration-dependent energy production and chicken colonization. Mol. Microbiol. 68(2):474-91.

McLennan, M.K., Ringoir, D.D., Frirdich, E., Svensson, S.L., Wells, D.H. Jarrell, H., Szymanski, C.M., and Gaynor, E.C. (2007) “Campylobacter jejuni biofilms up-regulated in a stringent response mutant utilize a calcofluor white-reactive polysaccharide.” J Bacteriol., 90(3):1097-107.

Candon, H.L., Allan, B.J., Fraley, C.D., and Gaynor, E.C. (2007) “Polyphosphate kinase 1 (PPK1) is a pathogenesis determinant in Campylobacter jejuni.” J Bacteriol. 189:8099-108.

Lupp, C., Robertson, M.L., Wickham, M.E., Sekirov, I., Champion, O.L., Gaynor, E.C., and Finlay, B.B. (2007). “Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriacaea.” Cell Host and Microbe 2:204

Mouery, K., Rader, B.A., Gaynor, E.C., and Guillemin, K. (2006) “The stringent response is required for Helicobacter pylori survival of stationary phase, exposure to acid, and aerobic shock.” J Bacteriol. 188:5494-500.

Wells DH, Gaynor EC. Helicobacter pylori initiates the stringent response upon nutrient and pH downshift.
J Bacteriol. 2006 May;188(10):3726-9.

Gaynor EC, Wells DH, MacKichan JK, and Falkow S.  The Campylobacter jejuni stringent response controls specific stress survival and virulence-associated phenotypes.  Mol Microbiol. 2005 Apr;56(1):8-27.

MacKichan JK, Gaynor EC, Chang C, Cawthraw S, Newell DG, Miller JF, and Falkow S.   The Campylobacter jejuni dccRS two-component system is required for optimal in vivo colonization but is dispensable for in vitro growth.  Mol Microbiol. 2004 Dec;54(5):1269-86.

Gaynor, E.C., Cawthraw, S., Manning, G., MacKichan, J.K., Falkow, S., and Newell, D.G. (2004) The genome-sequenced variant of Campylobacter jejuni NCTC11168 and the original clonal clinical isolate differ markedly in colonization, gene expression, and virulence-associated phenotypes. J Bact 186:503-17.

Leonard EE 2nd, Takata T, Blaser MJ, Falkow S, Tompkins LS, and Gaynor EC.  Use of an open-reading frame-specific Campylobacter jejuni DNA microarray as a new genotyping tool for studying epidemiologically related isolates.  J Infect Dis. 2003 Feb 15;187(4):691-4.

Gaynor EC, Ghori N, and Falkow S.  Bile-induced 'pili' in Campylobacter jejuni are bacteria-independent artifacts of the culture medium.  Mol Microbiol. 2001 Mar;39(6):1546-9.