Publications

Complete publication list in Google Scholar

Selected Recent Publications

  1. Verstraete M.M., Perez-Borrajero C., Brown K.L., Heinrichs D.E., & Murphy M.E.P. (2018) SbnI is a free serine kinase that generates O-phospho-L-serine for staphyloferrin B biosynthesis in Staphylococcus aureus. J. Biol. Chem. 2018 Feb 26. pii: jbc.RA118.001875. doi: 10.1074/jbc.RA118.001875.
  2. Liu, M.M., Boinett, C.J., Chan, A.C.K., Parkhill, J., Murphy*. M.E.P. & Gaynor*, E.C. (2018) Investigating the Campylobacter jejuni transcriptional response to host intestinal extracts reveals the involvement of a widely conserved iron uptake system. mBio. doi:10.1128/mBio.01347-18.
  3. Bowden, C.M.F., Chan, A.C.K., Li, E.J.W., Arrieta, A.L., Eltis, L.D. & Murphy, M.E.P. (2018) Structure-function analyses reveal key features in Staphylococcus aureus IsdB-associated unfolding of the heme-binding pocket of human hemoglobin. J. Biol. Chem. 293, 177-190.
  4. El-Halfawy, O.M., Klett, J., Ingram, R.J., Loutet, S.A., Murphy, M.E.P., Martín-Santamaría, S., and Valvano, M.A. (2017)
 Antibiotic capture by bacterial lipocalins uncovers an extracellular mechanism of intrinsic 
antibiotic resistance. mBio 8: e00225-17.
  5. Kobylarz, M.J., Heieis, G.A., Loutet, S.A. & Murphy, M.E.P. (2017) Iron Uptake Oxidoreductase (IruO) Uses a Flavin Adenine Dinucleotide Semiquinone Intermediate for Iron-Siderophore Reduction. ACS Chem. & Biol. 12: 1778-86. doi: 10.1021/acschembio.7b00203.
  6. Pfaffen, S., Bradley, J.M., Abdulqadir, R., Firme, M.R., Moore, G.R, Le Brun, N.E. and Murphy, M.E.P. (2015) A diatom ferritin optimized for iron oxidation but not iron storage. J. Biol. Chem. 290: 28416-27. (doi: 10.1074/jbc.M115.669713)
  7. Bowden, C.M.F., Verstraete, M.M., Eltis, L.D. & Murphy, M.E.P. (2014) The IsdB NEAT domain 1 of Hemoglobin binding and catalytic heme extraction by IsdB NEAT domains. Biochemistry. 53, 2286-94.
  8. Kobylarz, M.J., Grigg, J.C., Takayama, S.J., Rai, D.Y., Heinrichs, D.E., and Murphy, M.E.P. (2014) Synthesis of L-2,3-diaminopropionic acid, a siderophore and antibiotic precursor. Chem. & Biol. (Cell Press). 21, 379-88.
  9. Loutet, S.A., Kobylarz, M.J. Chau, C.H.T. & Murphy, M.E.P. (2013) IruO is a reductase for heme degradation by IsdI and IsdG proteins in Staphylococcus aureus. J. Biol. Chem. 288, 25749-59.
  10. Pfaffen, S., Abdulqadir, R., Le Brun, N.E. & Murphy M.E.P. (2013) Mechanism of ferrous iron binding and oxidation by ferritin from a pennate diatom. J. Biol. Chem. 288, 14917-25.
  11. Cheung, J., Murphy, M.E.P. & Heinrichs, D.E. (2012) Discovery of a novel, iron-regulated citrate synthase in Staphylococcus aureus. Chem. & Biol. (Cell press), 19, 1568-78.
  12. Ukpabi, G., Takayama, S.J., Mauk, A.G. & Murphy, M.E.P. (2012) Inactivation of IsdI heme oxidation by an active site substitution that diminishes heme ruffling. J. Biol. Chem. 287, 34179-88.
  13. Grigg, J.C., Mao, C.X., & Murphy, M.E.P. (2011) Iron coordinating tyrosine is a key determinant of NEAT domain heme transfer. J. Mol. Biol. 413: 684-98.
  14. Takayama, S.J., Ukpabi, G., Murphy*, M.E.P. & Mauk*, A.G. (2011) Electronic properties of the highly ruffled heme center of the heme degrading enzyme IsdI. Proc. Nat. Acad. Sci., 108: 13071-6.
  15. Koch, D., Chan, A.C.K., Murphy, M.E.P., Lilie, H., Grass, G. & Nies, D.H. (2011) Characterization of a novel dipartite iron uptake system from uropathogenic Escherichia coli strain F11. J. Biol. Chem. 286, 25317-30.
  16. Gaudin, C.F.M., Grigg, J.C., Arrieta, A.L., & Murphy, M.E.P. (2011) Unique axial tyrosine and methionine heme iron coordination in a NEAT domain from Staphylococcus aureus IsdB. Biochemistry, 50, 5443-52.
  17. Marchetti, A., Parker, M.S., Moccia, L.P., Lin, E.O., Arrieta, A.L., Murphy, M.E.P., Maldonado, M.T. & Armbrust, E.V. (2009) Ferritin is used for iron storage in bloom-forming marine pennate diatoms. Nature 457, 467-470.